2,6-Dichloropurine → 2-Chloroadenine

HRID 2269074Notes

Reaction equation

HRID 2269074 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[NH3:12].CO>>[NH2:12][C:4]1[N:3]=[C:2]([Cl:1])[N:10]=[C:9]2[C:5]=1[NH:6][CH:7]=[N:8]2

Participants

3

Reactant 2

HCID 53244122,6-DichloropurineHCID 21705897Ammonia methanol

Product 1

HCID 949042-Chloroadenine

Procedure

A solution of 2,6-dichloropurine 0.5 g (2.7 mmol) in 30% ammonia-methanol solution was heated at 100° C. in autoclave for 12 hours. The solution was condensed to give the subject compound. The compound may be used in next reaction without further purification.

Workup

  1. customcondensed
  2. customto give the subject compound
  3. customThe compound may be used in next reaction without further purification

Sources & evidence

ORD record
ord-56ebd2a3f7e54747940383986eb2ad61
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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