Dimethylformamide → HCID 18332807, compound

Participants

Reaction Conditions

Reaction Steps

To DMF suspension (10 ml) containing sodium hydride (300 mg, 7.5 mmol 60% in mineral oil) were added 2-propanethiol (1.0 ml, 11 mmol) and 6-amino-9-benzyl-2-chloropurine (160 mg, 0.62 mmol) in order. The mixture was stirred under heating at 100° C. for 2.5 hours. Brine was added thereto and the mixture was extracted with chloroform. The organic layer was dried on magnesium sulfate, filtered and the solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (112 mg, yield 61%).

Provenance & Evidence