Dimethylformamide → HCID 18332711, compound

Participants

Reaction Conditions

Reaction Steps

To DMF suspension (10 ml) containing sodium hydrate (300 mg, 7.5 mmol, 60%in mineral oil) were added 2-butanethiol (1 ml, 11 mmol) and 6-amino-9-benzyl-2-chloropurine (200 mg, 0.77 mmol) in order. The mixture was stirred under heating at 100° C. for 5 hours. Brine was added thereto and the mixture was extracted with chloroform. The organic layer was dried on magnesium sulfate, filtered and the solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (85 mg, yield 35%).

Provenance & Evidence