9-Benzyl-2-chloro-9h-purin-6-amine → HCID 18332754, compound

Participants

Reaction Conditions

Reaction Steps

6-Amino-9-benzyl-2-chloropurine (200 mg, 0.77 mmol) and sodium thiophenolate (2 g, 15 mmol) were mixed in DMF (12 ml) and then the mixture was stirred under heating at 100° C. for 7.5 hours. To the reaction mixture was added brine and the mixture was extracted with ethyl acetate. The organic layer was dried on magnesium sulfate, filtered and the solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (0.5% methanol/chloroform) to give the subject compound (228 mg, yield 89%).

Provenance & Evidence