9-Benzyl-2-chloro-9h-purin-6-amine → HCID 12777827, compound

Participants

Reaction Steps

6-Amino-9-benzyl-2-chloropurine (200 mg, 0.77 mmol) and sodium butylate (370 mg, 3.85 mmol) were dissolved in 1-butanol (20 ml) and then the solution was refluxed on heating under stirring for 2 hours. The reaction mixture was evaporated in vacuo to dryness. To the residue was added water and the mixture was extracted with chloroform. The organic layer was dried on sodium sulfate and evaporated in vacuo to dryness. The residue was purified with silica gel chromatography (2% methanol/chloroform) to of give the subject compound (131 mg, yield 54%).

Provenance & Evidence