反应详情

6-Amino-9-benzyl-2-chloropurine (200 mg, 0.77 mmol) and aqueous ethylamine (50 ml) were heated at 120° C. for 20 hours in autoclave. The reaction mixture was condensed in vacuo. To the residue was added 5N aqueous sodium hydroxide and the mixture was extracted with chloroform. The organic layer was dried on sodium sulfate, filtered and the solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (147 mg, yield 71%).

1. customcondensed in vacuo
2. extractionthe mixture was extracted with chloroform
3. customThe organic layer was dried on sodium sulfate
4. filtrationfiltered
5. customthe solvent in the filtrate was evaporated in vacuo
6. customThe residue was purified with silica gel chromatography (2% methanol/chloroform)