Cyclohexylamine → HCID 18332744, compound

Participants

Reaction Steps

6-Amino-9-benzyl-2-chloropurine (200 mg, 0.77 mmol) and cyclohexylamine (764 mg, 7.70 mmol) in 1-butanol (10 ml) were refluxed on heating for 60 hours. The reaction mixture was condensed in vacuo. To the residue was added 5N aqueous sodium hydroxide and the solution was extracted with chloroform. The organic layer was dried on sodium sulfate, filtered and the solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (115 mg, yield 46%).

Provenance & Evidence