Dimethylamine → HCID 18332773, compound

Participants

Reaction Steps

6-Amino-9-benzyl-2-chloropurine (100 mg, 0.385 mmol) and aqueous dimethylamine (30 ml) were heated at 120° C. for 15 hours in autoclave. The reaction mixture was condensed in vacuo. To the residue was added 5N aqueous sodium hydroxide and the solution was extracted with chloroform. The organic layer was dried on sodium sulfate, filtered and the solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (90 mg, yield 87%).

Provenance & Evidence