Bromine → HCID 18332721, compound

Participants

Reaction Steps

6-Amino-2-anilino-9-benzylpurine (87 mg, 0.31 mmol) was dissolved in a mixture of methylene chloride (50 ml) and acetic acid (10 ml). To the solution were added sodium acetate (105 mg, 1.28 mmol) and bromine (0.5 ml), and the mixture was stirred at room temperature for 3 hour. Aqueous sodium thiosulfate was added to the reaction mixture. The organic layer was separated, washed with aqueous saturated sodium hydrogen carbonate, dried on sodium sulfate and filtered. The solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (93 mg, yield 92%).

Provenance & Evidence