反应详情

6-Amino-9-benzyl-8-bromo-2-(2-methoxyethyl)aminopurine (68 mg, 0.18 mmol) was dissolved in 28% sodium methoxide in methanol (30 ml) and the solution was refluxed on heating under stirring for 4 hours. The reaction mixture was concentrated in vacuo to dryness and to the residue was added water. The mixture was extracted with chloroform and the organic layer was dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (26 mg, yield 44%).

1. temperaturethe solution was refluxed
2. temperatureon heating
3. concentrationThe reaction mixture was concentrated in vacuo to dryness and to the residue
4. additionwas added water
5. extractionThe mixture was extracted with chloroform
6. customthe organic layer was dried on sodium sulfate
7. concentrationconcentrated in vacuo to dryness
8. customThe residue was purified with silica gel chromatography (2% methanol/chloroform)