Bromine → HCID 18332755, compound

Participants

Reaction Steps

6-Amino-9-benzyl-2-(2-ethoxyethoxy)purine (300 mg, 0.96 mmol) and bromine (2.0 ml) were dissolved in methylene chloride (50 ml). The solution was stirred at room temperature for 1 hour. Aqueous sodium thiosulfate was added to the reaction mixture. The organic layer was separated, dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (256 mg, yield 68%).

Provenance & Evidence