Hydrochloric Acid → HCID 178508405, compound

Participants

Reaction Conditions

Reaction Steps

To sodium hydride (300 mg, 7.5 mmol 60% in mineral oil) were added DMF (10 ml), 3-mercaptopropionic acid (1 ml, 11 mmol) and 6-amino-9-benzyl-2-chloropurine (200 mg, 0.77 mmol) in order. The mixture was stirred at 100° C. for 5 hours. After addition of saturated brine, the reaction mixture was acidified with 2N hydrochloric acid and extracted with chloroform. The organic layer was dried on magnesium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (4% methanol/chloroform) to give the subject compound (120 mg, yield 47%).

Provenance & Evidence