Methanol → HCID 53785557, compound

Participants

Reaction Steps

To 3-(6-amino-9-benzyl-2-purinyl) thiopropionic acid (100 mg, 0.30 mmol) suspended in 10 ml of chloroform was added thionylchloride (0.14 ml, 2 mmol). After refluxing under heating for 1 hour methanol was dropped to the mixture under ice cooling. The solvent was removed in vacuo and the residue was purified by silica gel chromatography (1% methanol/chloroform) to give the subject compound (70 mg, yield 68%).

Provenance & Evidence