HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → N-(6-bromomethyl-pyridin-2-yl)-2,2,2-trifluoro-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | 2-Amino-6-methylpyridine | HCID 15765 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2,2,2-trifluoro-N-(6-methylpyridin-2-yl)acetamide | HCID 3643958 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(6-bromomethyl-pyridin-2-yl)-2,2,2-trifluoro-acetamide | HCID 57754672 | — |
Reaction Steps
2,2,2-trifluoro-N-(6-methyl-pyridin-2-yl)-acetamide xxii can be prepared from 6-methyl-pyridin-2-ylamine and trifluoroacetic anhydride in DCM. Radical bromination of xxii with N-bromosuccinimide and benzoyl peroxide in refluxing carbon tetrachloride affords N-(6-bromomethyl-pyridin-2-yl)-2,2,2-trifluoro-acetamide xxiii.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557213B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-9cbcaa9802c84d30917a5b15fc2551e1 |
| Source note | uspto-grants-2009_07 |