4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride → 4-(4-Fluoro-phenyl)-piperidine hydrochloride

Participants

Reaction Steps

To a solution of 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride (10 g) in methanol (200 mL) was added 10% palladium on charcoal (0.5 g) and the mixture was hydrogenated at 50 psi for 3 h. The catalyst was removed by filtration and solvent was evaporated to leave the product as a white powder, which was used in the next step without any purification.

Provenance & Evidence