HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,3S)-2-Phenyl-3-(5-(2,2,2-trifluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine → (2S,3S)-2-Phenyl-3-(5-(2,2,2-trifluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,3S)-2-Phenyl-3-(5-(2,2,2-trifluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine | HCID 15549736 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S,3S)-2-Phenyl-3-(5-(2,2,2-trifluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochloride | HCID 86757650 | 83% |
Reaction Steps
To a solution of Compound 14 (160 mg) in CH2Cl2 (10 ml) was added an excess amount of 10% HCl-MeOH (6 ml). After the solvent was evaporated in vacuo, the residual solid was recrystallized from IPA to give Compound 15 (130 mg, 83%; three steps) as a colorless crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329396B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-1f5a8a7fa10f4113816b6e2ee061c48d |
| Source note | uspto-grants-2001_12 |