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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2269249Generated: October 29, 2026

5-(1,2,2,2-Tetrafluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzaldehyde → (2S,3S)-2-Phenyl-3-(5-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochloride

https://huagongshe.com/reaction/2269249

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(1,2,2,2-Tetrafluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzaldehydeHCID 18677623—
Reactant(2S, 3S)-3-(2-Fluoro-5-(trifluoromethyl)benzyl)amino-2-phenylpiperidine dihydrochlorideHCID 86757652—
Product(2S,3S)-2-Phenyl-3-(5-(1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl)-2-methoxybenzyl)aminopiperidine dihydrochlorideHCID 86757651—

Reaction Steps

This compound was prepared from Compound 1 and Compound 17 in the same manner of Compound 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06329396B1
Source datasetuspto-grants-2001_12
ORD IDord-caba4f4fd78b4a5192eb893a135a2a8d
Source noteuspto-grants-2001_12