HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → (2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine | HCID 57090611 | — |
| Product | (2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochloride | HCID 86757653 | 87% |
Reaction Steps
The Compound 27 (360 mg. 0.87 mmol) was treated with methanol-hydrogen chloride (ca 20 ml) and the solvent was evaporated in vacuo to give crude product as a white solid. The crude product was recrystallized from ethanol-diethyl ether to give Compound 28 (370 mg, 87%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329396B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-3987f048170e4a53a966df39d3971fcd |
| Source note | uspto-grants-2001_12 |