Ethyl Acetate → 3-(3,4-Dimethyl-benzoyl)-1-(2-fluoro-benzyl)-6-trifluoromethyl-1H-quinolin-4-one

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Reaction Steps

Compound 4f was prepared following the procedure described in Step 3 of Example 1. Briefly described here, 55 mg (0.16 mmol) of 3-(3,4-dimethyl-benzoyl)-6-trifluoromethyl-1H-quinolin-4-one 3b, 8 mg (0.21 mmol) of 60% sodium hydride and 40 mg (0.21 mmol) of 2-fluorobenzyl bromide were combined in 0.5 mL N,N-dimethylformamide at rt for 16 h. Flash chromatography of the crude product using 10-80% ethyl acetate in hexane yielded 58 mg of the product 4f as white solid: LC-MSD, m/z for C26H19F4NO2 [M+H]+=454.5, HPLC retention time: 2.9 min: 1H NMR (400 MHz, CDCl3): δ 2.3 (s, 3H), 2.35 (s, 3H), 5.5 (s, 2H), 7.05-7.2 (m, 4H), 7.3-7.4 (m, 1H), 7.5-7.6 (m, 2H), 7.65 (s, 1H), 7.8-7.85 (m, 1H), 8.3 (s, 1H), 8.75-8.8 (m, 1H).

Provenance & Evidence