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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2269261Generated: October 26, 2026

(2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine → (2S,3S)-1-tert-Butoxycarbonyl-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino2-phenylpiperidine

https://huagongshe.com/reaction/2269261

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidineHCID 11311934—
Reactant2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzaldehydeHCID 18677612—
ReactantHCID 70001814HCID 70001814—
Product(2S,3S)-1-tert-Butoxycarbonyl-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino2-phenylpiperidineHCID 86757655—

Reaction Steps

This Compound was prepared from Compound 12 and Compound 40 in the same manner of Compound 26. This was employed in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06329396B1
Source datasetuspto-grants-2001_12
ORD IDord-bc208fe01a4943d28dfab68309ed10b7
Source noteuspto-grants-2001_12