Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2269262Generated: October 30, 2026

(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine → (2S, 3S)-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino-2-phenylpiperidine

https://huagongshe.com/reaction/2269262

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidineHCID 57090611—
Reactant(2S,3S)-1-tert-Butoxycarbonyl-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino2-phenylpiperidineHCID 86757655—
Product(2S, 3S)-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino-2-phenylpiperidineHCID 57114467—

Reaction Steps

This compound was prepared from Compound 41 in the same manner of Compound 27.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06329396B1
Source datasetuspto-grants-2001_12
ORD IDord-691e2dfd7bdb4dfda63d35353885ef49
Source noteuspto-grants-2001_12