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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2269276Generated: October 27, 2026

(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine → (S,3S)-3-[5-(1,1-Dimethyl-2,2,2-trifluoroethyl)-2-methoxybenzylamino]-2-phenylpiperidine

https://huagongshe.com/reaction/2269276

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidineHCID 57090611—
Reactant(2S,3S)-1-tert-Butoxycarbonyl-3-[5-(1,1-Dimethyl-2,2,2-trifluoroethyl)-2-methoxybenzylamino]-2-phenylpiperidineHCID 69999884—
Product(S,3S)-3-[5-(1,1-Dimethyl-2,2,2-trifluoroethyl)-2-methoxybenzylamino]-2-phenylpiperidineHCID 44433394—

Reaction Steps

This compound was prepared from Compound 72 in the same manner of Compound 27.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06329396B1
Source datasetuspto-grants-2001_12
ORD IDord-0b6c307be9ac4303ae60f51ce8cf51a1
Source noteuspto-grants-2001_12