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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2269280Generated: October 27, 2026

(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride → (2S, 3S)-3-[5-[2,2-Difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride

https://huagongshe.com/reaction/2269280

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochlorideHCID 70000615—
Reactant(2S,3S)-1-tert-Butoxycarbonyl-3-[5-[2,2-difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidineHCID 70001040—
Product(2S, 3S)-3-[5-[2,2-Difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochlorideHCID 86757656—

Reaction Steps

This compound was prepared from Compound 80 in the same manner of Compound 60.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06329396B1
Source datasetuspto-grants-2001_12
ORD IDord-5ed5ee8c1894457c9987ed0f7f6c9c35
Source noteuspto-grants-2001_12