(2S,3S)-3-((6-Methoxy-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine → (2S,3S)-3-((6Methoxy-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine dihydrochloride

HRID 2269287Notes

Reaction equation

HRID 2269287 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH2:13][NH:14][C@H:15]1[CH2:20][CH2:19][CH2:18][NH:17][C@H:16]1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH:9]([C:27]([F:30])([F:29])[F:28])[CH2:8][CH2:7][CH2:6]2.[ClH:31].Cl.FC(C1C=CC(OC(F)(F)F)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)(F)C>>[ClH:31].[ClH:31].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH2:13][NH:14][C@H:15]1[CH2:20][CH2:19][CH2:18][NH:17][C@H:16]1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH:9]([C:27]([F:30])([F:28])[F:29])[CH2:8][CH2:7][CH2:6]2

Participants

3

Reactant 2

HCID 44593634(2S,3S)-3-((6-Methoxy-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidineHCID 86757653(2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochloride

Product 1

HCID 70000778(2S,3S)-3-((6Methoxy-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine dihydrochloride

Procedure

This compound was prepared from Compound 93 in the same manner of Compound 28.

Sources & evidence

ORD record
ord-5c10ebc536c44140950c418de54b0951
Source dataset
uspto-grants-2001_12
Patent number
US06329396B1

Reaction notes

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