(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride → (2S,3S)-3-((2,2-Difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine dihydrochloride

HRID 2269289Notes

Reaction equation

HRID 2269289 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][C:22]([F:27])([F:26])[CH2:23]3)=[CH:18][C:17]=2[O:28][CH3:29])[C@@H:9]1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=O)(C)(C)C.[ClH:36].Cl.CC(C1C=CC(OC)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)(C)C#CC(F)(F)F>>[ClH:36].[ClH:36].[F:27][C:22]1([F:26])[CH2:21][CH2:20][C:19]2[C:24](=[CH:25][C:16]([CH2:15][NH:14][C@H:10]3[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]3[C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)=[C:17]([O:28][CH3:29])[CH:18]=2)[CH2:23]1

Participants

3

Reactant 2

HCID 70000615(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochlorideHCID 70001230(2S,3S)-1-tert-Butoxycarbonyl-3-((2,2-difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine

Product 1

HCID 69999940(2S,3S)-3-((2,2-Difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine dihydrochloride

Procedure

This compound was prepared from Compound 97 in the same manner of Compound 60.

Sources & evidence

ORD record
ord-4f41e7c5fcd342bc9423f1948ce176ed
Source dataset
uspto-grants-2001_12
Patent number
US06329396B1

Reaction notes

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