Methanol → 3-(5,6-Dimethyl-pyridine-2-carbonyl)-1H-quinolin-4-one

Participants

Reaction Steps

Compound 3d was prepared following the procedure outlined in Step 2 of Example 1 using 575 mg (1.77 mmol) of 2-(5,6-dimethyl-pyridine-3-carbonyl)-3-phenylamino-acrylic acid ethyl ester 2e, 30 mL of diphenyl ether. The reaction time was 2 h. Flash chromatography using 50-100% ethyl acetate in hexane followed by 0-30% methanol in ethyl acetate yielded 100 mg of the product 3d as off-white solid: LC-MSD, m/z for C17H14N2O2 [M+H]+: 279.4, HPLC retention time: 0.4 min.

Provenance & Evidence