Acetonitrile → HCID 20712338, compound

Participants

Reaction Conditions

Reaction Steps

To a solution 1-[4-(4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid allyloxy-amide (0.14 g, 0.29 mmol), triethylammonium formate (0.35 mL of a 3M solution in water, 1.0 mmol) and acetonitrile (1.5 mL) was added tetrakistriphenylphosphine palladium (0.033 g, 0.029 mmol). After stirring for 30 min at 90-100° C., the mixture was cooled to room temperature and concentrated in vacuo and purified by silica gel chromatography eluting with 1:1 to 1:0 ethyl acetate-hexane, affording 0.030 g of 1-[4-(4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-3-methyl-piperidine-2-carboxylic acid hydroxyamide as a colorless solid after trituration from CH2Cl2-hexane:

Provenance & Evidence