Trifluoroacetic acid → HCID 70073493, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2S)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylaminohexanoic acid 1,3,4-thiadiazol-2-ylamide (0.81 g, 1.75 mmol) in dichloromethane (8 mL) is added trifluoroacetic acid (2 mL). The resulting solution is stirred for 4 h at 25° C., is concentrated, diluted with 50 mL of EtOAc, and washed with 1 N aqueous sodium hydroxide solution. The organic layer is dried over anhydrous sodium sulfate and concentrated under reduced pressure to provide (2S)-6-benzyloxycarbonylamino-2-aminohexanoic acid 1,3,4-thiadiazol-2-ylamide as a solid (0.62 g, 98% yield).

Provenance & Evidence