Ammonia → HCID 18334179, compound

HRID 2269377Notes

Reaction equation

HRID 2269377 reaction equation
C[O:2][C:3]1[C:4](=[O:33])[C:5](=O)[C:6]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)[NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:9]=1.[NH3:34]>C(O)C>[NH2:34][C:5]1[C:4](=[O:33])[C:3](=[O:2])[C:6]=1[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([C:24]2[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=2)[NH:15][CH2:16][CH2:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18334092HCID 18334092, compound

Product 1

HCID 18334179HCID 18334179, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a similar manner to that described in Example (1d), 3-methoxy-4-{3-[(4-methoxyphenyl)-(2-phenylethylamino)methyl]phenylamino}-3-cyclobutene-1,2-dione (1.88 g) [prepared as described in step (c) above] and a solution of ammonia in ethanol (2N, 8.4 ml) were reacted, to give the title compound (1.66 g) as a yellow solid.

Sources & evidence

ORD record
ord-bc427f2ef9fa48cd8c678a83ff37a025
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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