Sodium borohydride → HCID 18334214, compound

HRID 2269378Notes

Reaction equation

HRID 2269378 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-])=O)[CH:21]=2)[NH:10][CH2:11][CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])=[CH:5][CH:4]=1.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([NH:10][CH2:11][CH:12]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH3:13])[C:20]2[CH:21]=[C:22]([NH2:26])[CH:23]=[CH:24][CH:25]=2)=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18347044HCID 18347044, compound

Product 1

HCID 18334214HCID 18334214, compoundYield 86.4%

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1b), a solution of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-(2-phenylpropyl)amine (3.17 g) [prepared as described in step (a) above] in methanol (60 ml), nickel chloride hexahydrate (3.7 g) and sodium borohydride (1.18 g) were reacted, to afford the title compound (2.52 g) as a clear purple oil.

Sources & evidence

ORD record
ord-efaba67c36314830a6d0d369f21bbe91
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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