3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 18347041, compound

HRID 2269379Notes

Reaction equation

HRID 2269379 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:17][CH2:18][CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH3:20])[C:10]2[CH:11]=[C:12]([NH2:16])[CH:13]=[CH:14][CH:15]=2)=[CH:5][CH:4]=1.[CH3:27][O:28][C:29]1[C:30](=O)[C:31](=[O:35])[C:32]=1[O:33]C>CO>[CH3:27][O:28][C:29]1[C:32](=[O:33])[C:31](=[O:35])[C:30]=1[NH:16][C:12]1[CH:13]=[CH:14][CH:15]=[C:10]([CH:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[NH:17][CH2:18][CH:19]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH3:20])[CH:11]=1

Participants

4

Reactant 2

HCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 18334214HCID 18334214, compound

Product 1

HCID 18347041HCID 18347041, compoundYield 70.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1c), a solution of 3-[(4-methoxyphenyl)-(2-phenylpropylamino)methyl]phenylamine (2.52 g) [prepared as described in step (b) above] in methanol (25 ml) and 3,4-dimethoxy-3-cyclobutene-1,2-dione (1.09 g) were reacted, to afford the title compound (2.35 g) as a pink foamy solid.

Sources & evidence

ORD record
ord-ec4e1b8edfe943f8bdb34954f01a4e77
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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