3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 18347043, compound

HRID 2269384Notes

Reaction equation

HRID 2269384 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:17][CH2:18][CH:19]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:10]2[CH:11]=[C:12]([NH2:16])[CH:13]=[CH:14][CH:15]=2)=[CH:5][CH:4]=1.[CH3:32][O:33][C:34]1[C:35](=O)[C:36](=[O:40])[C:37]=1[O:38]C>CO>[CH3:32][O:33][C:34]1[C:37](=[O:38])[C:36](=[O:40])[C:35]=1[NH:16][C:12]1[CH:13]=[CH:14][CH:15]=[C:10]([CH:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[NH:17][CH2:18][CH:19]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 18334202HCID 18334202, compound

Product 1

HCID 18347043HCID 18347043, compoundYield 52.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1c), a solution of 3-[(4-methoxyphenyl)-(2,2-diphenylethylamino)methyl]phenylamine (2.02 g) [prepared as described in step (b) above] in methanol (40 ml) and 3,4-dimethoxy-3-cyclobutene-1,2-dione (731 mg) were reacted, to afford the title compound (1.35 g) as a white foamy solid.

Sources & evidence

ORD record
ord-ae88f32dcce54b44876b2657cf5d023c
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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