Sodium borohydride → HCID 18334167, compound

HRID 2269386Notes

Reaction equation

HRID 2269386 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-])=O)[CH:21]=2)[NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)=[CH:5][CH:4]=1.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[C:20]2[CH:21]=[C:22]([NH2:26])[CH:23]=[CH:24][CH:25]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 18334187HCID 18334187, compound

Product 1

HCID 18334167HCID 18334167, compoundYield 83.9%

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1b), a solution of N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]-N-[2-(3-fluorophenyl)ethyl]amine (2.51 g) [prepared as described in step (a) above] in methanol (50 ml), nickel chloride hexahydrate (3.14 g) and sodium borohydride (1.0 g) were reacted, to afford the title compound (1.94 g) as a yellow oil.

Sources & evidence

ORD record
ord-a9f943aace5245e9a7af9331d90210c0
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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