HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 18334204, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | [(3-Nitrophenyl)phenylmethyl]-[1-(3,5-difluorophenyl)ethyl]amine | HCID 18334106 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 18334204 | HCID 18334204 | 96.8% |
Reaction Steps
In a similar manner to that described in Example (1b), a solution of isomer B of [(3-nitrophenyl)-phenylmethyl]-[1-(3,5-difluorophenyl)ethyl]amine (890 mg) in methanol (20 ml), nickel chloride hexahydrate (1.14 g) and sodium borohydride (363 mg) were reacted, to afford isomer B of the title compound (791 mg) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-ae78d8a997b34e7387856c52c86dab1a |
| Source note | uspto-grants-2001_12 |