Sodium borohydride → 3-{(3,4-Dimethylphenyl)-[(S)-1-phenylethylamino]methyl}phenylamine

Participants

Reaction Steps

In a similar manner to that described in Example (1b), a solution of isomer A of N-[(3-nitrophenyl)-(3,4-dimethylphenyl)methyl]-N-[(S)-1-phenylethyl]amine (1.10 g) [prepared as described in step (a) above] in methanol (20 ml), nickel chloride hexahydrate (1.45 g) and sodium borohydride (469 mg) were reacted, to afford isomer A of the title compound (954 mg) as a yellow oil.

Provenance & Evidence