HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 3-{(3,4-Dimethylphenyl)-[(S)-1-phenylethylamino]methyl}phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 70189822 | HCID 70189822 | — |
| Catalyst | Dichloronickel;hexahydrate | HCID 11791229 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-{(3,4-Dimethylphenyl)-[(S)-1-phenylethylamino]methyl}phenylamine | HCID 70189331 | 77.8% |
Reaction Steps
In a similar manner to that described in Example (1b), a solution of isomer B of N-[(3-nitrophenyl)-(3,4-dimethylphenyl)methyl]-N-[(S)-1-phenylethyl]amine (1.19 g) in methanol (20 ml), nickel chloride hexahydrate (1.57 g) and sodium borohydride (500 mg) were reacted, to afford isomer B of the title compound (849 mg) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-2ae26db1f7fc4b028668ffe3061ca709 |
| Source note | uspto-grants-2001_12 |