Sodium borohydride → HCID 70189103, compound

Participants

Reaction Steps

In a similar manner to that described in Example (1b), N-[(2-chloro-5-nitrophenyl)phenylmethyl]-N-[(S)-1-phenylethyl]amine (2.58 g) [prepared as described in step (a) above], nickel chloride hexahydrate (3.33 g) and sodium borohydride (1.06 g) were reacted. The crude product was separated and purified by chromatography through a silica gel column using a 1:10 by volume mixture of ethyl acetate and toluene as the eluant, to afford isomer A (771 mg) as a colorless oil and isomer B (659 mg) as a pale yellow oil of the title compound.

Provenance & Evidence