Sodium borohydride → HCID 70189163, compound

Participants

Reaction Steps

In a similar manner to that described in Example (1b), a solution N-[(3-nitrophenyl)-(4-methoxyphenyl)methyl]-[(S)-1-(3,4-difluorophenyl)ethyl]amine (1.50 g) [prepared as described in step (a) above] in methanol (50 ml), nickel chloride hexahydrate (1.79 g) and sodium borohydride (600 mg) were reacted, and the reaction mixture was purified by chromatography through a silica gel column using a 1:8 by volume mixture of ethyl acetate and toluene as the eluant, to afford isomer A (199 mg) as a yellow oil and isomer B (290 mg) as a yellow oil of the title compound.

Provenance & Evidence