HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 70189770, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 18347115 | HCID 18347115 | — |
| Reactant | (1S)-1-(3-Fluorophenyl)ethan-1-amine--hydrogen chloride (1/1) | HCID 44828804 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 70189770 | HCID 70189770 | 99.1% |
Reaction Steps
In a similar manner to that described in Example (1a), 3-methoxy-3′-nitrobenzophenone (2.0 g), (S)-1-(3-fluorophenyl)ethylamine hydrochloride (2.73 g), triethylamine (6.50 ml), titanium tetrachloride (1.03 ml), sodium cyanoborohydride (2.15 g) and acetic acid (0.67 ml) were reacted, to afford the title compound (2.93 g) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-3be70c83845d445ea00edd7717be9778 |
| Source note | uspto-grants-2001_12 |