Sodium borohydride → HCID 70188108, compound

Participants

Reaction Steps

In a similar manner to that described in Example (1b), a solution of N-[(3-nitrophenyl)-(2-methoxyphenyl)methyl]-N-[(S)-1-(3-fluorophenyl)ethyl]amine (2.96 g) [prepared as described in step (a) above] in methanol (50 ml), nickel chloride hexahydrate (3.70 g) and sodium borohydride (1.24 g) were reacted, and the crude product was purified by reverse phase HPLC using a 40:60 by volume mixture of acetonitrile and an acetic acid buffer solution (water/acetic acid/triethylamine=1000:2:2) as the eluant, to afford isomer A of the title compound (540 mg) as a yellow oil and isomer B of the title compound (800 mg) as a yellow oil.

Provenance & Evidence