HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18334111, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 2-Amino-4'-methoxybenzophenone | HCID 12206459 | — |
| Reactant | Benzenemethanamine, 3,4-difluoro-α-methyl-, hydrochloride (1:1) | HCID 18347113 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 18334111 | HCID 18334111 | 59.6% |
Reaction Steps
In a similar manner to that described in Example (1a), 2-amino-4′-methoxybenzophenone (2.12 g), 1-(3,4-difluorophenyl)-ethylamine hydrochloride (2.60 g), triethylamine (7.8 ml), titanium tetrachloride (1.1 ml), sodium cyanoborohydride (2.34 g) and acetic acid (0.8 ml) were reacted, to afford a mixture of diastereomers of the title compound (2.05 g) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-4b4d12e415124301be07200c0300106b |
| Source note | uspto-grants-2001_12 |