Ammonia → HCID 18334080, compound

HRID 2269417Notes

Reaction equation

HRID 2269417 reaction equation
C[O:2][C:3]1[C:6](=[O:7])[C:5](=O)[C:4]=1[NH:9][C:10]1[CH:11]=[C:12]([N:16]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=2)[C:17](=[O:26])[CH:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH3:19])[CH:13]=[CH:14][CH:15]=1.[NH3:35]>C(O)C>[NH2:35][C:5]1[C:6](=[O:7])[C:3](=[O:2])[C:4]=1[NH:9][C:10]1[CH:11]=[C:12]([N:16]([C:27]2[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=2)[C:17](=[O:26])[CH:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH3:19])[CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18347133HCID 18347133, compound

Product 1

HCID 18334080HCID 18334080, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

In a similar manner to that described in Example (1d), a solution of N-[3-(2-methoxy-3,4-dioxo-1-cyclobutenylamino)phenyl]-N-(4-methoxyphenyl)-2-phenylpropionamide (600 mg) [prepared as described in step (b) above] in ethanol (4 ml) and a solution of ammonia in ethanol (2N, 6 ml) were reacted, to afford the title compound (521 mg) as a yellow solid.

Sources & evidence

ORD record
ord-edf10a5f9b3e40f095e96f3d9eab7c0f
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

Loading…