3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 18347061, compound

HRID 2269423Notes

Reaction equation

HRID 2269423 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[NH:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:28][O:29][C:30]1[C:31](=O)[C:32](=[O:36])[C:33]=1[O:34]C>>[CH3:28][O:29][C:30]1[C:33](=[O:34])[C:32](=[O:36])[C:31]=1[NH:2][C:3]1[CH:4]=[C:5]([CH:9]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=2)[NH:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[CH:13]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 18334244HCID 18334244, compound

Product 1

HCID 18347061HCID 18347061, compoundYield 98.1%

Procedure

In a similar manner to that described in Example (46e) N-[(3-aminophenyl)-(4-methoxyphenyl)methyl]-3-fluorobenzamide hydrochloride (244 mg) [prepared as described in step (b) above] and 3,4-dimethoxy-3-cyclobutene-1,2-dione (107 mg) were reacted, to afford the title compound (285 mg) as a white solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0004715cc0634c339094f6de79a237cf
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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