4-Fluorobenzoyl chloride → HCID 18334239, compound

HRID 2269424Notes

Reaction equation

HRID 2269424 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([NH2:20])[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=2)=[CH:6][CH:5]=1.[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=2)[NH:20][C:26](=[O:27])[C:25]2[CH:29]=[CH:30][C:22]([F:21])=[CH:23][CH:24]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 18334147HCID 18334147, compound

Product 1

HCID 18334239HCID 18334239, compoundYield 88.3%

Procedure

In a similar manner to that described in Example (46c) α-(4-methoxyphenyl)-3-nitrobenzylamine hydrochloride (1.51 g) [prepared as described in Example 46(b) above] and 4-fluorobenzoyl chloride (813 mg) were reacted, to afford the title compound (1.72 g) as a white solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-10204cee39cf47ce954a8ae3c72f026a
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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