3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 18334096, compound

HRID 2269425Notes

Reaction equation

HRID 2269425 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([CH:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=2)[NH:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:28][O:29][C:30]1[C:31](=O)[C:32](=[O:36])[C:33]=1[O:34]C>>[CH3:28][O:29][C:30]1[C:33](=[O:34])[C:32](=[O:36])[C:31]=1[NH:2][C:3]1[CH:4]=[C:5]([CH:9]([C:20]2[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=2)[NH:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 18347124HCID 18347124, compound

Product 1

HCID 18334096HCID 18334096, compoundYield 49.7%

Procedure

In a similar manner to that described in Example (46e) N-[(3-aminophenyl)-(4-methoxyphenyl)methyl]-4-fluorobenzamide hydrochloride (674 mg) [prepared as described in step (b) above] and 3,4-dimethoxy-3-cyclobutene-1,2-dione (250 mg) were reacted, to afford the title compound (399 mg) as a yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-a7eff9c139f84b8895087821a60cf91b
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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