Tetrabutylammonium Fluoride → HCID 18334185, compound

Participants

Reaction Steps

A mixture of N-[2-(t-butyl-dimethylsilyloxy)-2-phenylethyl]-N-[(4-methoxyphenyl)-(3-nitrophenyl)methyl]amine (4.95 g) [prepared as described in step (a) above] and a solution of tetrabutylammonium fluoride in tetrahydrofuran (1M, 20 ml) was stirred at ambient temperature for 1 hour. The reaction mixture was diluted with ethyl acetate, and the ethyl acetate was washed with water and with an aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and then evaporated under reduced pressure. The residue was purified by chromatography through a silica gel column using a 3:1 by volume mixture of cyclohexane and ethyl acetate as the eluant, to afford the title compound (3.26 g) as a pale yellow oil.

Provenance & Evidence