3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 18347025, compound

HRID 2269432Notes

Reaction equation

HRID 2269432 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:17][CH2:18][CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[OH:20])[C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:27][O:28][C:29]1[C:30](=O)[C:31](=[O:35])[C:32]=1[O:33]C>CO>[OH:20][CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:18][NH:17][CH:8]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)[C:4]1[CH:3]=[C:2]([NH:1][C:30]2[C:31](=[O:35])[C:32](=[O:33])[C:29]=2[O:28][CH3:27])[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 18334157HCID 18334157, compound

Product 1

HCID 18347025HCID 18347025, compoundYield 45.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner to that described in Example (1c), a solution of 2-{[(3-aminophenyl)-(4-methoxyphenyl)methyl]amino}-1-phenylethanol (2.2 g) [prepared as described in step (c) above] in methanol (40 ml) and 3,4-dimethoxy-3-cyclobutene-1,2-dione (940 mg) were reacted, to afford the title compound (1.32 g) as a white foamy solid.

Sources & evidence

ORD record
ord-62a202cf6d2d4ebab99dad5d81e9c87a
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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