Ammonia → HCID 18334166, compound

HRID 2269433Notes

Reaction equation

HRID 2269433 reaction equation
[OH:1][CH:2]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:3][NH:4][CH:5]([C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=1)[C:6]1[CH:7]=[C:8]([NH:12][C:13]2[C:14](=[O:20])[C:15](=[O:19])[C:16]=2OC)[CH:9]=[CH:10][CH:11]=1.[NH3:35]>C(O)C>[NH2:35][C:16]1[C:15](=[O:19])[C:14](=[O:20])[C:13]=1[NH:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([CH:5]([NH:4][CH2:3][CH:2]([OH:1])[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18347025HCID 18347025, compound

Product 1

HCID 18334166HCID 18334166, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a similar manner to that described in Example (1d), 3-{3-[(2-hydroxy-2-phenylethylamino)-(4-methoxyphenyl)methyl]phenylamino}-4-methoxy-3-cyclobutene-1,2-dione (1.35 g) [prepared as described in step (d) above] and a solution of ammonia in ethanol (2N, 19 ml) were reacted, to give the title compound (1.36 g) as a yellow solid.

Sources & evidence

ORD record
ord-8a99ed589a5e475d9c4fc388bb8577eb
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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