3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 18347088, compound

Participants

Reaction Steps

In a similar manner to that described in Example (1c), a solution of the mixture (2.15 g) of 3-{(4-methoxyphenyl)-[2-(cyclohexen-1-yl)ethylamino]methyl}phenylamine and 3-[(4-methoxyphenyl)-(2-cyclohexylethylamino)methyl]phenylamine [prepared as described in step (b) above] in methanol (40 ml) and 3,4-dimethoxy-3-cyclobutene-1,2-dione (953 mg) were reacted, to afford a crude product, which was purified by reverse phase medium pressure chromatography using a 50:50 by volume mixture of acetonitrile and an aqueous acetic acid buffer solution (water/acetic acid/triethylamine=1000/2/2) as the eluant, to afford the title compound (815 mg) as a pale orange foamy solid.

Provenance & Evidence