HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(3-methoxyphenyl)methyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Benzenemethanamine, 3,4-difluoro-α-methyl-, hydrochloride (1:1) | HCID 18347113 | — |
| Reactant | 2-Methoxy-5-nitrophenyl 3-methoxyphenyl ketone | HCID 70189213 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[1-(3,4-Difluorophenyl)ethyl]-N-[(2-methoxy-5-nitrophenyl)-(3-methoxyphenyl)methyl]amine | HCID 18334104 | 92.8% |
Reaction Steps
Following a similar procedure to that described in Example (1a), 600 mg of 2-methoxy-5-nitrophenyl 3-methoxyphenyl ketone, 809 mg of 1-(3,4-difluorophenyl)ethylamine hydrochloride, 1.75 ml of triethylamine, 0.28 ml of titanium tetrachloride, 583 mg of sodium cyanoborohydride and 0.18 ml of acetic acid were reacted, to obtain 830 mg of the title compound as a yellow foamy solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06329405B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-edc6aec86af149528e2a0491c8b65974 |
| Source note | uspto-grants-2001_12 |